Publications

• Original articles
• Reviews

Original articles

2024

1. Specific protonation of acidic residues confers K⁺ selectivity to the gastric proton pump
   Madapally, H.V., Abe, K., Dubey, V. & Khandelia, H.
   J. Biol. Chem., 300, 105542 (2024) DOI: 10.1016/j.jbc.2023.105542

-2023 (selected)

1. A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities
   *Artigas, P., Meyer, D.J., Young, V.C., Spontarelli, K., Eastman, J., Strandquist, E., Rui, H., Roux, B., Brik, M., Nakanishi, H., *Abe, K. & *Gatto, C.
   Proc. Natl. Acad. Sci. USA., 120, e2313999120 (2023) DOI: 10.1073/pnas.2313999120
2. Deep learning driven de novo drug design based on gastric proton pump structures.
   *Abe K., Ozako, M., Inukai, M., Matsuyuki, Y., Kitayama, S., Kanai, C., Nagai, C., Gopalasingam, C.C., Gerle, C., Shigematsu, H., Umekubo, N., *Yokoshima, S. & *Yoshimori, A.
   Commun. Biol., 6, 956 (2023) DOI: 10.1038/s42003-023-05334-8
3. Structure and function of H⁺/K⁺ pump mutants reveal Na⁺/K⁺ pump mechanism.
   ^†Young, V.C., ^†Nakanishi, H., Meyer, D.J., Nishizawa, T., Artigas, P. & *Abe, K.
   Nat. Commun., 13, 5270 (2022) DOI: 10.1038/s41467-022-32793-0
4. Structural basis for binding of potassium-competitive acid blockers to the gastric proton pump.
   Tanaka, S., Morita, M., Yamagishi, T., Hridya, V.M., Hayashida, K., Khandelia, H., Gerle, C., Shigematsu, H., Oshima, A. & *Abe K.
   J. Med. Chem., 65, 7843-7853 (2022) DOI: 10.1021/acs.jmedchem.2c00338
5. Gastric proton pump with two occluded K⁺ engineered with sodium pump-mimetic mutations.
   *Abe, K., Yamamoto, K., Irie, K., Nishizawa, T. & Oshima, A.
   Nat. Commun., 12, 5709 (2021) DOI: 10.1038/s41467-021-26024-1
6. Transport cycle of plasma membrane flippase ATP11C by cryo-EM.
   Nakanishi, H., Nishizawa, T., Irie, K., Segawa, K., Nureki, O., Fujiyoshi, Y., Nagata, S. & *Abe, K.
   Cell Rep., 32, 108208 (2020) DOI:  10.1016/j.celrep.2020.108208 
7. A single K⁺-binding in the crystal structure of the gastric proton pump.
   Yamamoto, K., Dubey, V., Irie, K., Nakanishi, H., Khandelia, H., Fujiyoshi, Y. & *Abe, K.
   eLife, 8, e47701 (2019) DOI: 10.7554/eLife.47701
8. Crystal structures of the gastric proton pump.
   *Abe, K., Irie, K., Nakanishi, H., Suzuki, H. & Fujiyoshi, Y.
   Nature, 556, 214-218 (2018) DOI: 10.1038/s41586-018-0003-8
9. Cryo-EM structure of gastric H⁺,K⁺-ATPase with a single occupied cation-binding site.
   *Abe, K., Tani, K., Friedrich, T. & Fujiyoshi, Y.
   Proc. Natl. Acad. Sci. USA., 109 (45), 18401-18406 (2012) DOI: 10.1073/pnas.1212294109
10. Inter-subunit interaction of gastric H⁺,K⁺-ATPase prevents reverse reaction of the transport cycle.
    Abe, K., Tani, K., Nishizawa, T. & *Fujiyoshi, Y.
    EMBO J., 28, 1637-1643 (2009) DOI:  10.1038/emboj.2009.102

Reviews

1. Human F-ATP synthase as a drug target
   Gerle, C., Jiko, C., Nakano, A., Yokoyama, K., Gopalasingam, C.C., Shigematsu, H., *Abe, K.,
   Pharm Res (2024) DOI:10.1016/j.phrs.2024.107423
2. 細胞膜リン脂質フリッパーゼATP11Cの立体構造と輸送機構.
   中西華代, *阿部一啓
   生化学 (2022) DOI: 10.14952/SEIKAGAKU.2021.930824
3. 胃の酸性化の分子メカニズム.
   *阿部一啓
   生体の科学, 71, 310-314 (2020) DOI: 10.11477/mf.2425201181
4. 胃の中が強い酸性になる仕組み.
   *阿部一啓
   生物物理, 59, 73-78 (2019) DOI: 10.2142/biophys.59.073