{"id":37,"date":"2024-02-09T11:09:15","date_gmt":"2024-02-09T02:09:15","guid":{"rendered":"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/?page_id=37"},"modified":"2024-07-17T10:41:09","modified_gmt":"2024-07-17T01:41:09","slug":"research-en","status":"publish","type":"page","link":"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/research-en\/","title":{"rendered":"Research"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Research<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Development of Catalytic Asymmetric C\u2013H Transformation Reactions<\/h3>\n\n\n\n<p>Catalytic and site-selective C\u2013H bond transformations of organic molecules is a powerful method for accessing complex compounds through short-step synthetic processes. In direct transformation of methylene C\u2013H bonds having different substituents (R<sup>1<\/sup>\u2013CH<sub>2<\/sub>\u2013R<sup>2<\/sup>), depending on which of two carbon-hydrogen bonds is converted, the product becomes a chiral compound with a mirror image molecular structure such as right and left hands. With a focus on weak interactions that act between catalysts and chemical substances, we are working on the development of new asymmetric synthesis methods to obtain pure chiral compounds through direct transformation of carbon\u2013hydrogen bonds.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"467\" src=\"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-content\/uploads\/2024\/07\/r1.jpg\" alt=\"\" class=\"wp-image-594\" srcset=\"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-content\/uploads\/2024\/07\/r1.jpg 640w, https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-content\/uploads\/2024\/07\/r1-300x219.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><figcaption class=\"wp-element-caption\">Ligands of Organic Synthetic Catalysts<\/figcaption><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\">Development of Photon-Driven Transformative Chemical Reactions<\/h3>\n\n\n\n<p>Promotion of a chemical reaction requires energy supply. Heat is a common energy source in common chemical reactions. In contrast, we are trying to develop entirely new chemical reactions that make use of \u201clight\u201d as an energy source. Since light can provide much higher energy than heat, we will be able to realize novel reactions that were ever thought to be impossible. However, the molecule activated by the high energy of light is prone to decompose via unexpected side reactions. We are developing transformative chemical reactions by controlling behaviors of the activated molecules by molecular design and by collaborating with metal catalysts.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"480\" src=\"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-content\/uploads\/2024\/07\/r2.png\" alt=\"\" class=\"wp-image-596\" style=\"width:640px;height:auto\" srcset=\"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-content\/uploads\/2024\/07\/r2.png 640w, https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-content\/uploads\/2024\/07\/r2-300x225.png 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><figcaption class=\"wp-element-caption\">Photo-driven Chemical Reaction<\/figcaption><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\">Quantum Chemical Calculations for Designing Asymmetric Synthesis Catalysts<\/h3>\n\n\n\n<p>As molecular creators, we have designed various catalysts and developed revolutionary asymmetric reactions, driven by our knowledge, experience, and imagination. In addition to this, we have been developing innovative asymmetric synthesis catalysts by elucidating the working principles of the catalysts through the use of quantum chemical calculations, and applying the knowledge gained from these calculations to the design of new catalysts. By maximizing the use of quantum chemical calculations, including the cutting-edge AFIR method developed by Professor Maeda in the Theoretical Chemistry Laboratory, we are able to take a rational approach to the creation of high-performing catalysts.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"480\" src=\"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-content\/uploads\/2024\/07\/r3.png\" alt=\"\" class=\"wp-image-597\" srcset=\"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-content\/uploads\/2024\/07\/r3.png 640w, https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-content\/uploads\/2024\/07\/r3-300x225.png 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><figcaption class=\"wp-element-caption\">Quantum Chemical Calculations for Catalyst Design<\/figcaption><\/figure>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Research Development of Catalytic Asymmetric C\u2013H Transformation Reactions Cataly &#8230; <\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-37","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-json\/wp\/v2\/pages\/37","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-json\/wp\/v2\/comments?post=37"}],"version-history":[{"count":3,"href":"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-json\/wp\/v2\/pages\/37\/revisions"}],"predecessor-version":[{"id":606,"href":"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-json\/wp\/v2\/pages\/37\/revisions\/606"}],"wp:attachment":[{"href":"https:\/\/wwwchem.sci.hokudai.ac.jp\/~orgmet\/wp-json\/wp\/v2\/media?parent=37"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}