業績一覧
~2004

Publication（論文）

2002

  • Kuwata, K.,Gongora, C., Kanno, Y., Sakaguchi, K., Tamura, T., T, Kanno, T., Basrur, V., Martinez, R.,Appella, E., Golub, T. and Ozato, K.: Gamma Interferon g triggers the interaction between ICSBP (IRF-8) and TEL recruiting the histone deacetylase HDAC3 to the interferon responsive element. Mol. Cell. Biol. 22:7439-7448, 2002.
  • Kawano, M., Okada, K., Honnda, T., Nose, T., Sakaguchi, K., Costa, T. and Shimohigashi, Y.: Structural Requirements of Nociceptin Antagonist Ac-RYYRIK-NH2 for Receptor Binding. J. Peptide Sci. 8:561-569, 2002.
  • Kar, S., Sakaguchi, K., Shimohigashi, Y., Samaddar, S., Banerjee, R., Basu, G., Swaminathan, V., Kundu, T. K. and Roy, S.: Effect of Phosphorylation on the Structure and Fold of Transactivation domain of p53. J. Biol. Chem. 277: 15579-15585, 2002.

2000

  • Higashimoto, Y., Saito, S., Tong, X.-H., Hong, A., Sakaguchi, K., Appella, E., and Anderson, C.W.: Human p53 is phosphorylated on Serine 6 and 9 in response to DNA Damage-Inducing Agents. J. Biol. Chem. 275: 23199-23203, 2000.
  • Sakaguchi, K., Saito, S., Higashimoto, Y., Roy, S. Anderson, C.W., Appella, E.:Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding. J. Biol. Chem. 275: 9278-9283, 2000.
  • Bergman, A.C., Benjamin, T., Alaiya, A., Waltham, M., Sakaguchi, K., Franzen, B., Linder, S., Bergman, T., Auer, G., Appella, E., Wirth, P.J., and Jornvall, H.: Identification of gel-separated tumor marker proteins by mass spectrometry. Electrophoresis 21 : 679-686, 2000.
  • Appella E, Arnott D, Sakaguchi, K, and Wirth PJ.: Proteome mapping by two-dimensional polyacrylamide gel electrophoresis in combination with mass spectrometric protein sequence analysis. EXS 88: 1-27, 2000.

1999

  • Bulavin, D. V., Saito, S., Hollander, M.C., Sakaguchi, K., Anderson, C. W., Appella, E., and Fornace, A. J., Jr.: Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 18: 6845-6854, 1999.
  • Mazur, S. J., Sakaguchi, K., Appella, E., Wang, X. W., Harris, C. C., and Bohr, V. A.: Preferential Binding of Tumor Suppressor p53 to Positively or Negatively Supercoiled DNA Involves the C-Terminal Domain. J. Mol. Biol. 292: 241-249, 1999.
  • Jimenez, G. S., Bryntesson, F., Torres-Arzayus, M. I., Priestley, A., Beeche, M., Saito, S., Sakaguchi, K., Appella, E., Jeggo, P. A., Taccioli, G. E., Wahl, G. M., and Hubank, M: DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage. Nature 400: 81 – 83, 1999.
  • Delphin, C., Ronjat, M., Deloulme, J. C., Garin, G., Debussche, L., Higashimoto, Y., Sakaguchi, K., and Baudier, J.: Calcium-dependent interaction of S100B with the C-terminal domain of the tumor suppressor p53. J. Biol. Chem. 274: 10539-10544, 1999.
  • Chuman, Y, Bergman, A. C, Ueno, T., Saito, S., Sakaguchi, K., Alaiya, A. A., Franzen, B., Bergman, T., Arnott e, D., Auer d, G., Appella, E., Jornvall, H., Linder, S.: Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas. FEBS Lett. 462: 129-134, 1999.
  • Pike, S.E., Yao, L., Setsuda, J., Jones, K.D., Cherney, B., Appella, E., Sakaguchi, K., Nakhasi H., Atreya C.D., Teruya-Feldstein J., Wirth P., Gupta G., Tosato G.: Calreticulin and Calreticulin Fragments Are Endothelial Cell Inhibitors That Suppress Tumor Growth. Blood 94: 2461-2468, 1999.
  • Herrera, J. E., Sakaguchi, K., Bergel, M., Trieschmann, L., Nakatani, Y., and Bustin, M. Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes. Mol. Cell. Biol., 19: 3466-3473, 1999.
  • Bergman, A. C., Alaiya, A. A., Wendler, W., Binetruy, B., Shoshan, M., Sakaguchi, K., Bergman, T., Kronenwett, U., Auer, G., Appella, E., Jornvall, H., and Linder, S.:Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts. Cell. Mol. Life Sci., 55: 467-471, 1999.

1998

  • Sakaguchi, K., Herrera, J. E., Saito, S, Miki, T, Bustin, M., Vassilev, A., Anderson, C. W., and Appella, A.: DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12: 2831-2841, 1998.
  • Canman, C. E., Lim, D-S., Cimprich, K. A., Katsuyuki, Y. T., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., and Siliciano, J. D.: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281: 1677-1679, 1998.
  • Pise-Masison, C. A., Radonovich, M., Sakaguchi, K., Appella, E., Brady, J. N.: Phosphorylation of p53: a novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells. J. Virol. 72: 6348-6355, 1998.
  • Munoz-Barroso, I., Durell, S., Sakaguchi, K., Appella, E., Blumenthal, R.: Dilation of the human immunodeficiency virus-1 envelope glycoprotein fusion pore revealed by the inhibitory action of the a synthetic peptide from gp41. J. Cell Biol. 140: 315-323, 1998.
  • Kawakami, Y., Robbins, P. F., Wang, X., Tupesis, J. P., Parkhurst, M. R., Kang, X. Q., Sakaguchi, K., Appella, E., and Rosenberg, S. A.: Identification of new melanoma epitopes on melanosomal proteins recognized by tumor infiltrating T lymphocytes restricted by HLA-A1, -A2, and -A3 alleles. J. Immunol. 161: 6985-6992, 1998.
  • Kim, P. J., Sakaguchi, K., Sakamoto, H., Saxinger, C., Day, R., McPhie, P., Rubin, J. S., and Bottaro, D. P.: Colocalization of heparin and receptor binding sites on keratinocyte Growth factor. Biochemistry 37: 8853-8862, 1998.
  • Pike, S. E., Yao, L., Jones, K. D., Cherney, B., Appella, E., Sakaguchi, K., Nakhasi, H., Teruya-Feldstein, J., and Wirth, P.: Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth. J. Exp. Med. 188: 2349-2356, 1998.

1997

  • Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., Kastan, M. B.: DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev. 11: 3471-3481, 1997.
  • Sakaguchi, K., Sakamoto, H., Lewis, M. S., Anderson, C. W., Erickson, J. W., Appella, E., and Xie, D.: Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53. Biochemistry 36: 10117-10124, 1997.
  • Fiscella, M., Zhang, H.-L., Fan, S., Sakaguchi, K., Shen, S., Mercer, W. E., Vande Woude, G. F., O’Connor, P. M., and Appella, E.: Wip1, a novel human protein phosphatase that is induced in response to IR in a p53-dependent manner. Proc. Natl. Acad. Sci. USA 12: 6048-6053, 1997.
  • Sakaguchi, K., Sakamoto, H., Xie, D., Erickson, J. W., Lewis, M. C., Anderson, C. W., and Appella, E.: Effect of phosphorylation of tetramerization of the tumor suppressor protein p53. J. Protein Chem. 6: 553-556, 1997.
  • Del Guercio, M-F., Alexander, J., Kubo, R., Arrhenius, T., Maewal, A., Appella, E., Hoffman, S., Jones, T., Valmori, D., Sakaguchi, K., Grey, H. M., Sette, A.: Potent immunogenic short linear peptide constucts composed of B cell epitopes and Pan DR T Helper Epitopes (PADRE) for antibody responses in vivo. Vaccine 15: 441-448, 1997.
  • Tsai, V., Southwood, S., Sidney, J., Sakaguchi, K., Kawakami, Y., Appella, E., Sette, A., and Celis, E.: Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells. J. Immunol. 158: 1796-1802, 1997.
  • Bergman, A. C., Linder, C., Sakaguchi, K., Sten-Linde, R. M., Alaiya, A. A., Franzen, B., Shoshan, M. C., Bergman, T., Wiman, B., Auer, G., Appella, E,. Jornvall, H., and Linder S.: Increased expression of alpha-enolase in c-jun transformed rat fibroblasts without increased activation of plasminogen. FEBS Lett. 417:17-20, 1997.
  • Kimura, T., Zhang, J., Sagawa, K., Sakaguchi, K., Appella, E., and Siraganian, R. P.: Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor. J. Immunol. 59: 4426-4434, 1997.

1996

  • Miller, M., Lubkowski, J. , Mohana Rao, J. K., Danishefsky, A. T., Omichinski, J. G., Sakaguchi, K., Sakamoto, H., Appella, E., Gronenborn, A. M., and Clore, G. M.: The oligomerization domain of p53: crystal structure of the trigonal form. FEBS Lett. 399: 166-170, 1996.
  • Sakamoto, H., Kodama, H., Higashimoto, Y., Kondo, M., Lewis, M. S., Anderson, C. W., Appella, E. and Sakaguchi, K.: Chemical synthesis of phosphorylated peptides of the carboxy-terminal domain of human p53 by a segment condensation method. Int. J. Pept. Protein Res. 48: 429-442, 1996.
  • Di Marzo Veronese, F., Arnott, D., Barnaba, V., Loftus, D. J., Sakaguchi, K., Thompson, C. B., Salemi, S., Mastroianni, C., Sette, A., Shabanowitz, J., Hunt, D. F., and Appella, E.: Autoreactive cytotoxic T lymphocytes in human immunodeficiency virus type-1 infected subjects. J. Exp. Med. 183: 2509-2516, 1996.
  • Fineschi, B., Sakaguchi, K., Appella, E., and Miller, J.: The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 forms of invariant chain. J. Immunol. 157: 3211-3215, 1996.
  • D’Oro, U., Sakaguchi, K., Appella, E. and Ashwell, J. D.: Mutational analysis of Lck in CD45-negetive T cells. Mol. Cell. Biol. 16: 4996-5003, 1996.
  • Sakaguchi, K., Roller, P. P. and Appella, E.: Chemical synthesis and applications of phosphopeptides. In Setlow J. K. (Ed.): Genetic Engineering: Principles and Methods, Vol. 18, New York, Plenum, pp. 249-278, 1996.

1995

  • Clubb, T. R., Omichinski, J. G., Sakaguchi, K., Appella, E., Gronenborn, M. A. and Clore, G. M.: Backbone dynamics of the oligomerization domain of p53 determined from 15N NMR relaxation measurements. Protein Science 4; 855-862, 1995.
  • Clore, G. M., Ernst, J., Clubb, R., Omichinski, J. G., Sakaguchi, K., Appella, E. and Gronenborn, A. M.: Refined solution structure of the oligomerization domain of the tumor suppressor p53. Nature Struct. Biol. 2: 321-338, 1995.
  • Clore, G. M., Omichinski, J. G., Sakaguchi, K., Zambrano, N., Sakamoto, H., Appella, E. and Gronenborn, A. M.: Interhelical angles in the solution structure of the oligomerization domain of the tumor suppressor p53. Science 267: 1515-1516, 1995.
  • Kang, X., Kawakami, Y., Sakaguchi, K., Wang, R., El-Gamil, M., Yannelli, R. J., Appella, E., Rosenberg, S. A. and Robbins, P. F.: Identification of a tyrosinase epitope recognized by HLA-A24 restricted tumor-infiltrating lymphocytes. J. Immunol. 155: 1343-1348, 1995.
  • Robbins, P. F., El-Gamil, M., Yong, L., Topalian, S., Rivoltini, L., Sakaguchi, K., Appella, E., Kawakami, Y. and Rosenberg, S. A.: Cloning of a new gene recognized by melanoma-specific HLA-A24 restricted tumor infiltrating lymphocytes. J. Immunol. 154: 5944-5950, 1995.
  • Grohmann, U., Puccetti, P., Belladonna, M. L.., Fallarino, F., Bianchi, R., Binaglia, L., Sakaguchi, K., Mage, M. G., Appella, E. and Fioretti, M. C.: Multiple point mutations in an endogenous retroviral gene confer high immunogenicity on a drug-treated murine tumor. J. Immunol. 154: 4631-4641, 1995.
  • Rivoltini, L., Kawakami, Y., Sakaguchi, K., Southwood, S., Sette, A., Robbins, P. F., Marincola, F. M., Salgaller, M. L., Yannelli, J. R., Appella, E. and Rosenberg, S. A.: Induction of tumor reactive CTL from peripheral blood and tumor infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1. J. Immunol. 154: 2257-2265, 1995.
  • Kawakami, Y., Eliyahu, S., Jennings, C., Sakaguchi, K., Kang, X., Southwood, S., Robbins, P. F., Sette, A., Appella, E. and Rosenberg, S. A.: Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor infiltrating T-lymphocytes associated with in vivo tumor regression. J. Immunol. 154: 3961-3968, 1995.
  • Loftus, J. D., Kubo, R. T., Sakaguchi, K., Celis, E., Sette, A. and Appella, E.: Analysis of MHC-Specific Peptide Motifs: Applications in Immunotherapy. Adv. Exp. Med. Biol. 383: 201-210, 1995.
  • Appella, E., Loftus, J. D., Sakaguchi, K., Sette, A. and Celis, E.: Synthetic Antigenic Peptides as a New Strategy for Immunotherapy of Cancer. Biomedical Peptides, Proteins and Nucleic Acids, 1: 177-184, 1995.

1994

  • Clore, G. M., Omichinski, J. G., Sakaguchi, K., Zambrano, N., Sakamoto, H., Appella, E., and Gronenborn, A. M.: High-resolution solution structure of the oligomerization domain of p53 by multi-dimentional NMR. Science 265: 386-391, 1994.
  • Sakamoto, H., Lewis, M. S., Kodama, H., Appella, E., and Sakaguchi, K.: Specific sequences from the carboxy-termines of human p53 form anti-parallel tetramers in solution. Proc. Natl. Acad. Sci. USA 91: 8974-8978, 1994.
  • Wondrak, E. M., Sakaguchi, K., Rice, W. G., Kun, E., Kimmel, A. R., and Louis, J. M.: Removal of zinc is required for processing of the mature nucleocapsid protein of human immunodeficiency virus, type 1, by the viral protease. J. Biol. Chem. 269: 21948-21950, 1994.
  • Kawakami, Y., Eliyahu, S., Sakaguchi, K., Robbins, P. F., Rivoltini, L., Yannelli, J. R., Appella, E., and Rsenberg, S. A.: Identification of the immunodominat peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2 restricted tumor infiltrating lymphocytes. J. Exp. Med. 180: 347-352, 1994.
  • Kawakami, Y., Eliyahu, S., Delgado, C. H., Robbins, P. F., Sakaguchi, K., Appella, E., Yannelli, J. R., Adema, G. J., Miki, T., and Rosenberg, S. A.: Identification of a melanoma antigen recognized by tumor infiltrating lymphocytes associated with in vivo tumor rejection. Proc. Natl. Acad. Sci. USA 91: 6458-6462, 1994.
  • Sidney, J., Oseroff, C., Del Guercio, M.-F., Southwood S., Krieger J. I., Ishioka, G. Y., Sakaguchi, K., Appella, E., and Sette A.: Definition of a DQ3.1 specific binding motif. J. Immunol. 152: 4516-4525, 1994.
  • Franco, A., Appella, E., Kagnoff, M. F., Chowers, Y., Sakaguchi, K., Grey, H. M., Sette, A.: Peripheral T-Cell Response to A-gliadin in Celiac Disease. Differential processing and presentation capacities of Epstein-Barr transformed B cells and fibroblasts. Clinical Immunology and Immunopathology 71: 75-81, 1994.
  • Kubo, R. T., Sette, A., Grey, H. M., Appella, E., Sakaguchi, K., Zhu, N.-Z., Arnott, D., Sherman, N., Shabanowitz, J., Michel, H., Bodnar, W. M., Davis, T. A., and Hunt, D. F.: Definition of specific peptide motifa for four major HLA-A alleles. J. Immunol. 152: 3913-3924, 1994.
  • Chen, Y., Sidney, J., Southwood, S., Cox, A. L., Sakaguchi, K., Henderson, R. A., Appella, E., Hunt D. F., Sette, A., and Engelhard, V. H.: Naturally processed peptides longer than 9 amino acid residues bind to the class I MHC molecule HLA-A2.1 with high affinity and in different conformations. J. Immunol. 152: 2874-2881, 1994.
  • Sakaguchi, K., Kodama, H., Ogino, Y., Costa, T., Nose, T., and Shimohigashi, Y.: Structural essentials of Ser-1 in tethered peptide ligand of human thrombin. Bull. Chem. Soc. Jpn. 67: 1052-1056, 1994.
  • Burns, C. M., Sakaguchi, K., Appella, E., and Ashwell J. D.: CD45 regulation of COOH-terminal tyrosine phosphorylation and enzyme activity of src family kinases. J. Biol. Chem. 269: 13594-13600, 1994.
  • Bovolenta, C., Driggers, P. H., Marks, M. S., Medin, J. A., Politis, A. D., Vogel, S. N., Levy, D. E., Sakaguchi, K., Appella, E., Coligan J. E., and Ozato, K.: Molecular interactions between ICSBP and members of the interferon regulatory factor family. Proc. Natl. Acad. Sci. USA 91: 5046-5050, 1994.
  • Hipps, D. S., Packman, L. C., Sakaguchi, K., Appella, E., and Perham, R. N.: The peripheral subunit-binding domain of the dihydrolipoyl acetyltransferase component of the pyruvate dehydrogenase complex of Bacillus stearothermorphilius:: Preparation and characterization of its binding to the dihydrolipotl dehydrogenase component. Biochem. J. 297: 137-143, 1994.

1993

  • Ullrich, S. J., Sakaguchi, K., Lees-Miller, S., Anderson, C., Mercer, W. E., and Appella, E.: Phosphorylation of serines 15 and 392 in mutant p53 from natural tumors is altered compared to human p53. Proc. Natl. Acad. Sci. USA 90: 5954-5958, 1993.
  • Sakaguchi, K., Zambrano, N., Baldwin E. T., Shapiro, B. A., Erickson, J. W., Omichinski, J. G., Clore, G. M., Gronenborn, A. M., and Appella, E.: Identification of a binding site for the human immunodeficiency virus type 1 nucleocapsid protein. Proc. Natl. Acad. Sci. USA 90: 5219-5233, 1993.
  • Henderson, R. A., Cox, A. L., Sakaguchi, K., Appella, E., Shabanowitz, J., Hunt, D. F, and Engelhard, V. H.: Direct identification of an endogenous peptide recognized by multiple HLA-A2.1-specific cytotoxic T cells. Proc. Natl. Acad. Sci. USA 90: 10275-10279, 1993.
  • Huczko, E. L., Bonder, W. M., Benjamin, D., Sakaguchi, K., Zhu, N. Z., Shabanowitz, J., Henderson, R. A., Appella, E., Hunt, D. F., and Engelhard, V. H.: Characteristics of endogenous peptides eluted from the class I MHC molecule HLA-B7 determined by mass spectrometry and computer modeling. J. Immunol. 151: 2572-2587, 1993.
  • Wang, M.-H., Skeel, A., Yoshimura, T., Copeland, T. D., Sakaguchi, K., and Leonard, E. J.: Antibodies to macrophage stimulating protein (MSP): specificity, epitope interactions, and immunoassey of MSP in human seram. J. Leukoc. Biol. 54: 289-295, 1993.
  • Driscoll, P. C., Altman, J. D., Boniface, J. J., Sakaguchi, K., Reay, P. A., Omichinski, J. G., Appella, E., and Davis, M. M.: Two-dimensional nuclear magnetic resonance analysis of a labeled peptide bound to a class II major histocompatibility complex molecule. J. Mol. Biol. 232: 342-350, 1993.
  • Matsumoto, H., Shimohigashi, Y., Takano, Y., Sakaguchi, K., Kamiya, H., Ohno, M.: Optimum cross-linking spacer length of dimeric Neurokinin-B analogs for interaction with NK-1 tachykinin receptors. Bull. Chem. Soc. Jpn. 66: 196-204, 1993.
  • Gao, B., Virmani, M., Romm, E., Lazar-Wesley, E., Sakaguchi, K., Appella, E., Kunos, G., and Takacs, L.: Sequence of cDNA encoding bovine apolipoprotein H. Gene 126: 287-288, 1993.
  • Fazioli, F., Wong, W. T., Ullrich, S. J., Sakaguchi, K., Appella, E., and Di Fiore, P. P.: The ezrin-like family-of tyrosine kinase substrate: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation. Oncogene 8: 1335-1345, 1993.
  • Kalia, Y. N., Brocklehurst, S. M., Hipps, D. S., Appella, E., Sakaguchi, K., and Perham, R. N.: The high resolution structure of the peripheral subunit-binding domain of dihydrolipoamide acetyltransferase from the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilis. J. Mol. Biol. 230: 323-341, 1993.
  • Engelhard, V. H., Appella, E., Benjamin, D. C., Bonder, W. M., Cox, A. L., Chen, Y., Henderson, R. A., Huczko, E. L., Michel, H., Sakaguchi, K., Shabanowitz, J., Sevilir, N., Slingluff, C. L., and Hunt, D. F.: Mass spectrometric analysis of peptides associated with the human class I MHC molecules HLA-A2.1 and HLA-B7 and identification of structural features that determine binding. Chem. Immunol. 57: 39-62, 1993.

1992

  • Sette, A., Ceman, S., Kubo, R. T., Sakaguchi, K., Appella, E., Hunt, D. F., Davis, T. A., Michel, H., Shabanowitz, J., Rudersdorf, R., Grey, H. M., and DeMars, R.: Invariant chain peptides in most HLA-DR molecules of an antigen processing mutant. Science 258: 1801-1804, 1992.
  • Bristol, L. A., Sakaguchi, K., Appella, E., Doyle, D., and Takacs, L.: Thymocyte costimulating antigen is CD26 (dipeptidyl-peptidase IV): Costimulation of granulocyte, macrophage and T-lineage cell proliferation via CD26. J. Immunol. 149: 367-372, 1992.
  • Hunt, D. F., Michel, H., Dickinson, T. A., Shabanowitz, J., Cox, A. L., Sakaguchi, K., Appella, E., Grey, H. M., and Sette, A.: Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad. Science 256: 1817-1820, 1992.
  • Henderson, R. A.*, Michel, H.*, Sakaguchi, K.*, Shabanowitz, J., Appella, E., Hunt, D. F., and Engelhard, V. H.: HLA-A2.1-associated peptides from a mutant cell line: A second pathway of antigen presentation. Science 255: 1264-1266, 1992. (*co-first author)
  • Hunt, D. F.*, Henderson, R*. A., Shabanowitz*, J., Sakaguchi, K.*, Michel, H., Sevilir, N., Cox, A. L., Appella, E., and Engelhard, V. H.: Characterization of peptides bound to the class I MHC molecule, HLA-A2.1 by mass spectrometry. Science 255: 1261-1263, 1992. (*co-first author)
  • Lees-Miller, S. P., Sakaguchi, K., Ullrich, S. J., Appella, E., and Anderson, C. W.: Human DNA-activated protein kinase phosphorylates serines 15 and 37 the amino-terminal transactivation domain of human p53. Mol. Cell. Biol. 12: 5041-5049, 1992.
  • Omichinski, J. G., Clore, G. M., Robien, M., Sakaguchi, K., Appella, E., and Gronenborn, A. M.: High-resolution solution structure of the double Cys2His2 zinc finger from a human enhancer binding protein MBP-1. Biochemistry 31: 3907-3917, 1992.
  • Sakaguchi, K., Costa, T., Sakamoto, H., and Shimohigashi, Y.: Receptor interactions of synthetic morphiceptin analogs containing phenylalanine homologs in position 4. Bull. Chem. Soc. Jpn. 65: 1659-1663, 1992.
  • Olson, D., Pollanen, J., Hoyer-Hansen, G., Ronne, E., Sakaguchi, K., Wen, T.-C., Appella, E., Dano, K., and Blasi, F.: Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor. J. Biol. Chem. 267: 9129-9133, 1992.
  • Robien, M. A., Clore, G. M., Omichinski, J. G., Perham, R. N., Appella, E., Sakaguchi, K., and Gronenborn, A. M.: Three-dimensional solution structure of the E3-binding domain of the dihydrolipoamide sussinyltransferase core from the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli. Biochemistry 31: 3463-3471, 1992.

1991

  • Omichinski, J. G., Clore, G. M., Sakaguchi, K., Appella, E., and Gronenborn, A. M.: Structural characterization of a 39-residue synthetic peptide containing the two zinc binding domains from the HIV-1 p7 nucleocapsid protein by CD and NMR spectroscopy. FEBS Lett. 292: 25-30, 1991.
  • Sakaguchi, K., Appella, E., Omichinski, J. G., Clore, G. M., and Gronenborn, A. M.: Specific DNA binding to an MHC enhancer sequence by a synthetic 57-residue double zinc finger peptide from a human enhancer binding protein. J. Biol. Chem. 266: 7306-7311, 1991.
  • Demotz, K., Sette, A., Sakaguchi, K., Buchner, R., Appella, E., and Grey, H. D.: Self peptide requirement for Class II major histocompatibility complex allorecognition. Proc. Natl. Acad. Sci. USA 88: 8730-8734, 1991.

1990

  • Omichinski, J. G., Clore, G. M., Appella, E., Sakaguchi, K., and Gronenborn, A. M.: High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution. Biochemistry 29: 9324-9334, 1990.
  • Saito, R., Konishi, H., Takano, Y., Nonaka, S., Sakaguchi, K., Shimohigashi, Y., and Kamiya, H.: Characterization of tachykinin receptors in endothelial cells of porcine artery. Neuroscience Lett. 110: 337-342, 1990.
  • Sakaguchi, K., Sakamoto, H., Tsubaki, Y., Waki, M., Costa, T., and Shimohigashi, Y.: Opioid activities of morphiceptin analogs derived from ?-casein. Bull. Chem. Soc. Jpn. 63: 1753-1757, 1990.

1989

  • Shimohigashi, Y., Sakaguchi, K., Sakamoto, H., Waki, M., and Costa, T.: Opioid activities of morphiceptin-like peptide latent in various natural protein. Peptide Research 3: 216-223, 1990.
  • Sakaguchi, K., Kodama, H., Matsumoto, H., Yoshida, M. Takano, Y., Kamiya, H., Waki, M., and Shimohigashi, Y.: Design and synthesis of dimeric analogs of neurokinin A and B: effect of dimerization of COOH-terminal heptapeptides on receptor selection. Peptide Research 2: 345-351, 1989.
  • Higuchi, Y., Takano, Y., Shimazaki, H., Shimohigashi, Y., Kodama, H., Matsumoto, H., Sakaguchi, K., Nonaka, S., Saito, R., Waki, M., and Kamiya, H.: Dimeric substance P analogue (D-SP2-11) shows a highly potent activity of the in vivo salivary secretion of rat. Eur. J. Pharmacol. 160: 413-416, 1989.

1988

  • Imazu, S., Shimohigashi, Y., Kodama, H., Sakaguchi, K., Waki, M., Kato., T., and Izumiya, N.: Conformationally stabilized gramicidin S analog containing dehydrophenylalanine in place of D-phenylalanine4,4’: synthesis and antimicrobial activity. Int. J. Pept. Protein Res. 32: 298-306, 1988.
  • Kodama, H., Shimohigashi, Y., Sakaguchi, K., Waki, M., Takano, Y., Yamada, A., Hatae, Y., and Kamiya, H.: Dimerization of neurokinin A and B COOH-terminal heptapeptide fragments enhanced selectivity for tachykinin receptor subtypes. Eur.J. Pharmacol. 151: 317-320, 1988.

1987

  • Shimohigashi, Y., Kodama, H., Imazu, S. , Sakaguchi, K., Waki, M., Uchida, H., Kondo, M., and Izumiya, N.: 4,4’-(Z)-dehydrophenyl-alanine]gramicidin S with stabilized bioactive conformation and strong antimicrobial activity. FEBS Lett. 222: 251-255, 1987.