北海道大学 大学院理学研究院 化学部門

生物化学研究室

講演者

Prof. Kyou-Honn Han
（韓国生命工学研究院）

日時

平成22年6月16日（水）　17:30 –

場所

北海道大学理学部　7号館　7-219/220室

概要

A significant portion of protein kingdom is predicted to consist of proteins that, under non-denaturing conditions, do not form well-defined globular structures. These proteins, termed intrinsically unfolded proteins (IUPs), have attracted many bioinformatics researchers and structural biologists over the last decade, not only because of their peculiar structural characteristics but also for their involvement in several important diseases such as cancer, mad cow disease, viral diseases and Alzheimer disease. This talk will deliver a short overview on IUPs with an in-depth description of PreSMos (Pre-Structured Motifs) that act as active sites in IUPs by mediating protein-protein interactions. Discovery of IUPs has challenged the long-standing dogma in structural biology that a uniquely-defined three-dimensional structure is a prerequisite for protein function and is reshaping our notion on protein structure-function relationship.

主催

グローバルCOE物質科学イノベーション講演会

共催

日本生化学会北海道支部
日本生物物理学会北海道支部
生命分子化学セミナー

連絡先

北海道大学 大学院理学研究院 化学部門
生物化学研究室
坂口 和靖
TEL: 011-706-2698