お知らせ
2007年8月30日

【第16-1回】Regulation of the p53 tumor suppressor: posttranslational modifications and whole genome analysis of functional p53 binding sites.

講演者

Dr. Carl W. Anderson
(Chair, Biology Department, Brookhaven National Laboratory)

日時

平成19年8月30日(木) 14:00 – 16:00

場所

北海道大学理学部 6号館2階 204-2講義室

概要

The p53 tumor suppressor is a transcription factor that in normal cells has a short half-life but is stabilized and activated in response to cellular stresses including DNA double-strand breaks resulting from ionizing radiation. p53 binds to the consensus response element, and regulates the expression, both positively or negatively, of ~1500 genes. To develop a molecular understanding of the consequences of exposures to ionizing radiation, we are characterizing the functions of posttranslational modifications to p53 and the enzymes that produce or remove these, and we are developing methods for profiling the functional chromatin binding sites of p53 (and other proteins) in cells across whole genomes.

共催

日本生化学会北海道支部
生命分子化学セミナー
理学研究院 化学専攻 「魅力ある大学院教育イニシアチブ」

連絡先

北海道大学 大学院理学研究院 化学部門
生物化学研究室
坂口 和靖
TEL: 011-706-2698