発表論文
2024
184. Flash Sequence-Defined Molecular Synthesis Enabled by Living Anionic Monoaddition of Polymerizable Alkenes
Okamoto, K.; Yoo, D. E.; Yoshioka, R.; Nakasato, R.; Ashikari, Y.; Kitayama, K.; Nagaki, A.
ChemRXiv
DOI: 10.26434/chemrxiv-2024-jffkv-v2
183. Spatiotemporal Control of Protein Refolding through Flash-Change Reaction Conditions
Nakahara, Y.; Kawaguchi, T.; Matsuda, Y.; Endo, Y.; Date, M.; Takahashi, K.; Kato, K.; Okasora, T.; Ejima, D.; Nagaki, A.
Langmuir 2024, in press.
DOI: 10.1021/acs.langmuir.4c00024
182. Flowmicro In-Line Analysis-Driven Design of Reactions mediated by Unstable Intermediates: Flash Monitoring Approach
Ashikari, Y.; Yoshioka, R.; Yonekura, Y.; Yoo, D. E.; Okamoto, K.; Nagaki, A.
Chem. Eur. J. 2024, 30, e202303774.
DOI: 10.1002/chem.202303774
Selected as a Front Cover Picture.
DOI: 10.1002/chem.202400844
Cover profile
北海道大学プレスリリース
「70年の時を経てアニオン重合反応の活性種観測に成功～精密な高分子材料合成への貢献に期待～」
日刊工業新聞（2024年3月14日）
「北大、アニオン重合の反応制御 高分子材開発に知見提供」
181. Highly productive flow synthesis for lithiation, borylation, and/or Suzuki coupling reaction
Soutome, H.; Maekawa, K.; Ashikari, Y.; Nagaki, A.
Org. Process Res. Dev. 2024, in press.
DOI: 10.1021/acs.oprd.4c00021
180. Synthesis of Deuterated Compounds by Flow Chemistry
Kamio, S.; Okamoto, K.; Yamagishi, T.; Nagaki, A.
ChemPlusChem 2024, in press.
DOI: 10.1002/cplu.202300744
179. Elucidation of the kinetic stabilities of carbenoid species by integration of theoretical and experimental studies
Okamoto, K.; Muta, K.; Yamada, H.; Higuma, R.; Ashikari, Y.; Nagaki, A.
React. Chem. Eng. 2024, in press.
DOI: 10.1039/D3RE00648D
178. リビング重合の制御性向上に寄与するフローマイクロリアクターシステム
早乙女広樹、芦刈洋祐、永木愛一郎
リビング重合
サイエンス&テクノロジー
177. One-flow operation via 4-bromopyridine enables flash synthesis of AChE inhibitor
Soutome, H.; Kimuro, Y.; Kawaguchi, T.; Yoo, D. E.; Yao, Y.; Oshida, S.; Nakayama, H.; Iwata, M.; Ebisawa, R.; Kikuchi, R.; Tomite, K.; Wada, S.; Ashikari, Y.; Nagaki, A.
Synthesis 2024, 56, 821–827.
DOI: 10.1055/a-2218-9048
176. Reactions of Highly Volatile Organic Compounds with Organolithium Species in Flow Microreactor
Muta, K.; Okamoto, K.; Nagaki, A.
Synlett 2024, in press.
DOI: 10.1055/a-2170-2976
175. マイクロリアクターの特長を活かした環境調和型の精密高速合成化学
永木愛一郎
有機合成化学協会誌 2024, 82, 2–13.
DOI: 10.5059/yukigoseikyokaishi.82.2
174. A Manufacturing Strategy Utilizing a Continuous Mode Reactor toward Homogeneous PEGylated Bioconjugate Production
Nakahara, Y.; Endo, Y.; Takahashi, K.; Kawaguchi, T.; Kato, K.; Matsuda, Y.; Nagaki, A.
Synthesis 2024, 56, 597–602.
DOI: 10.1055/a-2077-6187
2023
173. AI技術を用いたフロー自動合成と実験の短縮（第7章3節）
芦刈洋祐、玉木孝、永木愛一郎
実験の自動化・自律化によるR&Dの効率化と運用方法 －AI、ロボット技術、ChatGPT、MI、ベイズ最適化、秘密計算など－
技術情報協会、2023年12月28日発刊
ISBN：978-4-86104-994-1. Link
172. 機械学習を活用したフローリアクター合成のプロセス最適化、自動化
芦刈洋祐、永木愛一郎
MATERIAL STAGE 2023, 23 (9), 41–45.
（技術情報協会マテリアルステージ2023年12月号）
Link
171. Electrocatalytic Reduction of (Hetero)Aryl Halides in a Proton-Exchange Membrane Reactor and its Application for Deuteration
Ashikari, Y.; Mandai, K.; Yao, Y.; Tsuchihashi, Y.; Nagaki, A.
ChemElectroChem 2023, 10, e202300315.
DOI: 10.1002/celc.202300315
Selected as a cover picture.
DOI:10.1002/celc.202300657
170. ベイズ最適化を活用したフロー合成研究事例
玉木孝、岡本和紘、永木愛一郎
PHARMSTAGE 2023, 23 (7), 13–18.
Link
169. フロー研究が導く有機化学の高速化
永木愛一郎、岡本和紘
Organometallic News 2023, 94–99.
DOI: 10.1055/a-2170-2976
168. External Flash Generation of Carbenoids Enables Monodeuteration of Dihalomethanes
Okamoto, K.; Higuma, R.; Muta, K.; Fukumoto, K.; Tsuchihashi, Y.; Ashikari, Y.; Nagaki, A.
Chem. Eur. J. 2023, 29, e202301738.
DOI: 10.1002/chem.202301738
Selected as a cover picture!
Link
167. 有機電解フロー反応による有用物質の高速合成
宅見正浩、永木愛一郎
ファルマシア 2023, 59 (9), 815–819.
DOI: 10.14894/faruawpsj.59.9_815
166. Continuous enantiomeric separation using water-oil-water segmented flow system
Muranaka, Y.; Maki, T.; Nakayoshi, D.; Asano, S.; Ikebata, K.; Nagaki, A.; Ashikari, Y.; Mandai, K.; Mae, K.
Chem. Eng. J. 2023, 469, 143891.
DOI: 10.1016/j.cej.2023.143891
165. Introduction to Flow Chemistry for the Synthetic Chemist (chepter 4)
Ashikari, Y.; Nagaki, A.
Enabling Tools and Techniques for Organic Synthesis: A Practical Guide to Experimentation, Automation, and Computation (Ed. Newman, S. G.)
Willy, published in October 2023
ISBN: 978-1-119-85563-7. Link
164. 中間体を自在に操り、高速な有機合成化学を
永木愛一郎
ドラマチック有機合成化学―感動の瞬間100
化学同人、2023年7月20日発刊
ISBN：978-4-7598-2336-3
163. AIによるフロー合成の反応条件最適化（第5章7節）
岡本和紘、永木愛一郎
ケモインフォマティクスにおけるデータ収集の最適化と解析手法
技術情報協会、2023年4月28日発刊
ISBN：978-4-86104-944-6
Link
162. Flow-Chemistry-Enabled Synthesis of 5-Diethylboryl-2,3′-bipyridine and Its Self-Assembly Dynamics
Wakabayashi, S.; Takumi, M.; Kamio, S.; Wakioka, M.; Ohki, Y.; Nagaki, A.
Chem. Eur. J. 2023, 29, e202202882.
DOI: 10.1002/chem.202202882
2022
161. Flash Functional Group-Tolerant Biaryl-Synthesis Based on Integration of Lithiation, Zincation and Negishi Coupling in Flow
Ashikari, Y.; Guan, K.; Nagaki, A.
Front. Chem. Eng. 2022, 4, 964767.
DOI: 10.3389/fceng.2022.964767
160. Rapid access to organic triflate based on flash generation of unstable sulfonium triflates in flow
Takumi, M.; Sakaue, H.; Shibasaki, D.; Nagaki, A.
Chem. Commun. 2022, 58, 8344–8347.
DOI: 10.1039/D2CC02344J
Selected as a back cover. Link
159. Rapid gas-liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide
Mandai, K.; Yamamoto, T.; Mandai, H.; Nagaki, A.
Beilstein J. Org. Chem. 2022, 18, 660–668.
DOI: 10.3762/bjoc.18.67
158. Glycosyl Dioxalenium Ions as Reactive Intermediates of Automated Electrochemical Assembly
Shibuya, A.; Kato, M.; Saito, A.; Manmode, S.; Nishikori, N.; Itoh, T.; Nagaki, A.; Nokami, T.
Eur. J. Org. Chem. 2022, 2022, e202200135.
DOI: 10.1002/ejoc.202200135
157. Flash Synthesis and Continuous Production of C-Arylglycosides in a Flow Electrochemical Reactor
Takumi, M.; Nagaki, A.
Front. Chem. Eng. 2022, 4, 862766.
DOI: 10.3389/fceng.2022.862766
156. Flash Electrochemical Approach to Carbocations
Takumi, M.; Sakaue, H.; Nagaki, A.
Angew. Chem. Int. Ed. 2022, 61, e202116177.
DOI: 10.1002/anie.202116177
京都大学プレスリリース：「高速なフロー電気分解を駆使してわずか20秒での医薬品合成に成功」
Chem-Station：「カチオン中間体の反応に新展開をもたらす新規フロー反応装置の開発」
JST NEWS：「高速の電気分解が可能な装置を開発 医薬品前駆体を合成、わずか19秒で」
155. Investigation of Parameter Control for Electrocatalytic Semihydrogenation in a Proton-Exchange Membrane Reactor Utilizing Bayesian Optimization
Ashikari, Y.; Tamaki, T.; Takahashi, Y.; Yao, Y.; Atobe, M.; Nagaki, A.
Front. Chem. Eng. 2022, 3, 819752.
DOI: 10.3389/fceng.2021.819752
154. フローマイクロケミストリーに基づく反応集積化
永木愛一郎、芦刈洋祐
THE CHEMICAL TIMES 2022, 263, 3–6.
Link (pdf)
153. Flow grams-per-hour production enabled by hierarchical bimodal porous silica gel supported palladium column reactor having low pressure drop
Ashikari, Y.; Maekawa, K.; Takumi, M.; Tomiyasu, N.; Fujita, C.; Matsuyama, K.; Miyamoto, R.; Bai, H.; Nagaki, A.
Catal. Today 2022, 388–389, 231–236.
DOI: 10.1016/j.cattod.2020.07.014
2021
152. Stille, Heck, and Sonogashira coupling and hydrogenation catalyzed by porous-silica-gel-supported palladium in batch and flow
Ashikari, Y.; Maekawa, K.; Ishibashi, M.; Fujita, C.; Shiosaki, K.; Bai, H.; Matsuyama, K.; Nagaki, A.
Green Process. Synth. 2021, 10, 722–728.
DOI: 10.1515/gps-2021-0069
151. フロー高速合成とAI活用の将来展望について
永木愛一郎、芦刈洋祐、宅見正弘
化学工学 2021, 85, 611-614.
Link
150. Switchable Chemoselectivity of Reactive Intermediates Formation and Their Direct Use in a Flow Microreactor
Ashikari, Y.; Tamaki, T.; Kawaguchi, T.; Furusawa, M.; Yonekura, Y.; Ishikawa, S.; Takahashi, Y.; Aizawa, Y.; Nagaki, A.
Chem. Eur. J. 2021, 27, 16107–16111.
DOI: 10.1002/chem.202103183
149. Flash Production of Organophosphorus Compounds in Flow
Tamaki, T.; Nagaki, A.
Tetrahedron Lett. 2021, 81, 153364.
DOI: 10.1016/j.tetlet.2021.153364
148. Principles of controlling reactions in flow chemistry
Nagaki, A.; Yoshida, J.
Vol. 1 Flow Chemistry-Fundamentals, 2nd ed. (Eds. Darvas, F.; Dormán, G.; Hessel, V.; Ley, S. V.)
Walter de Gruyter & Co., 2021年10月25日発刊, ISBN: 978-3-11-073679-3.
Link
147. 高速合成化学（第I編 第1章）
宅見正浩、永木愛一郎
146. 高分子合成反応（第I編 第6章）
芦刈洋祐、永木愛一郎
フローマイクロ合成の最新動向（監修：深瀬浩一、永木愛一郎）
シーエムシー出版、2021年8月31日発刊、ISBN：978-4-7813-1615-4.
Link
145. Multiple Organolithium Reactions based on Space Integration. (chapter 17)
Nagaki, A.
Middle Molecular Strategy: Flow Synthesis to Functional Molecules pp. 309-320.
Springer、2021年8月16日発刊、ISBN:978-981-16-2457-5
Link
144. 高速合成化学における反応選択性の制御
玉木 孝、永木 愛一郎
有機合成化学協会誌 2021, 79, 483-491.
DOI: 10.5059/yukigoseikyokaishi.79.483
143. Multiple Organolithium Reactions for Drug Discovery Using Flash Chemistry
Ashikari, Y.; Tamaki, T.; Takumi, M.; Nagaki, A.
Topics in Medicinal Chemistry 2021, Springer
DOI: 10.1007/7355_2021_113
142. Homogeneous Catalyzed Aryl–Aryl Cross-couplings in Flow
Ashikari, Y.; Nagaki, A.
Synthesis 2021, 53, 1879–1888.
DOI: 10.1055/a-1360-7798
141. Flash Chemistry Makes Impossible Organolithium Chemistry Possible
Nagaki, A. Ashikari, Y.; Takumi, M; Tamaki, T.
Chem. Lett. 2021, 50, 485–492.
DOI: 10.1246/cl.200837
Vol. 50 Commemorative Highlight Review: Molecular Chemistry
140. Insight into the Ferrier rearrangement by combining flash chemistry and superacids
Lebedel, L.; Yamashita, H.; Shimizu, Y.; Bhuma, N.; Abada, Z.; Ardá, A.; Désiré, J.; Michelet, B.; Mingot, A.; Abou-Hassan, A.; Takumi, M.; Jiménez-Barbero, J.; Nagaki, A.; Blériot, Y.; Thibaudeau, S.
Angew. Chem. Int. Ed. 2021, 60, 2036–2041.
DOI: 10.1002/anie.202010175
139. マイクロチャネル：マイクロ混合・反応（第2編第4章第3節）
芦刈洋祐、永木愛一郎
マイクロ・ナノ熱工学の進展
株式会社エヌ・ティー・エス、2021年5月19日発刊
ISBN:978-4-86043-722-0
Link
2020
138. A Synthetic Approach to Dimetallated Arenes Using Flow Microreactors and the Switchable Application to Chemoselective Cross-Coupling Reactions
Ashikari, Y.; Kawaguchi, T.; Mandai, K.; Aizawa, Y.; Nagaki, A.
J. Am. Chem. Soc. 2020, 142, 17039–17047.
DOI: 10.1021/jacs.0c06370
Selected as a Cover Picture
Highlighted in 現代化学 2020, 597, 11.
「マイクロフロー合成を利用してクロスカップリング反応」
137. Accelerating Heat-Initiated Radical Reactions of Organic Halides with Tin Hydride Using Flow Microreactor Technologies
Jiang, Y.; Ashikari, Y.; Guan, K.; Nagaki, A.
Synlett 2020, 31, 1937–1941.
DOI: 10.1055/s-0040-1707307
136. Trapping of Transient Thienyllithiums Generated by Deprotonation of 2,3- and 2,5-Dibromothiophenes in a Flow Microreactor
Okano, K.; Yamane, Y.; Nagaki, A.; Mori, A.
Synlett 2020, 31, 1913–1918.
DOI: 10.1055/s-0040-1706479
135. Pd catalysts supported on dual-pore monolithic silica beads for chemoselective hydrogenation under batch and flow reaction conditions
Yamada, T.; Ogawa, A.; Masuda, H.; Teranishi, W.; Fujii, A.; Park, K.; Ashikari, Y.; Tomiyasu, N.; Ichikawa, T.; Miyamoto, R.; Bai, H.; Matsuyama, K.; Nagaki, A.; Sajiki, H.
Catal. Sci. Technol. 2020, 10, 6359–6367.
DOI: 10.1039/D0CY01442G
134. マイクロリアクター、フロー合成分野の動向と展望(第1章)
永木愛一郎
133. フローリアクターを用いた合成反応、プロセス設計と応用例（第6章1節）
萬代恭子、永木愛一郎
132. フローマイクロリアクターの高速混合を利用した高選択的化学反応（第6章2節）
芦刈洋祐、永木愛一郎
131. フローリアクターを用いた不安定中間体を経由する反応集積化（第6章3節）
芦刈洋祐、永木愛一郎
130. フローリアクターを用いた有機電解合成（第6章4節）
宅見正浩、永木愛一郎
129. フローリアクターを用いた鈴木－宮浦カップリング反応（第6章6節）
前川圭、芦刈洋祐、永木愛一郎
128. フロー精密アニオン重合技術と実用化に向けた課題（第6章12節）
高橋祐輔、永木愛一郎
フロー合成、連続生産のプロセス設計、条件設定と応用事例
技術情報協会、2020年12月25日発刊、ISBN:978-4-86104-820-3
127. 時間を空間で制御する高分子合成化学
永木愛一郎、高橋祐輔
高分子 2020, 69, 355-358.
Link
126. Fluoro-Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors
Colella, M.; Tota, A.; Takahashi, Y.; Higuma, R.; Ishikawa, S.; Degennaro, L.; Luisi, R.; Nagaki, A.
Angew. Chem. Int. Ed. 2020, 59, 10924–10928.
DOI: 10.1002/anie.202003831
Highlighted in Synfacts
125. Bromine-lithium exchange on a gem-dibromoalkene. Part 2: comparative performance of flow micromixers
Perez, K.; Picard, B.; Vuluga, D.; Burel, F.; Hreiz, R.; Falk, L.; Commenge, J.-M.; Nagaki, A.; Yoshida, J.; Chataigner, I.; Maddaluno, J.; Legros, J.
Org. Process Res. Dev. 2020, 24, 787–791.
DOI: 10.1021/acs.oprd.0c00203
124. Synthesis of Biaryls Having a Piperidylmethyl Group Based on Space Integration of Lithiation, Borylation and Suzuki-Miyaura Coupling
Takahashi, Y.; Ashikari, Y.; Takumi, M.; Shimizu, Y.; Jiang, Y.; Higuma, R.; Ishikawa, S.; Sakaue, H.; Shite, I.; Maekawa, K.; Aizawa, Y.; Yamashita, H.; Yonekura, Y.; Colella, M.; Luisi, R.; Takegawa, T.; Fujita, C.; Nagaki, A.
Eur. J. Org. Chem. 2020, 618–622.
DOI: 10.1002/ejoc.201901729
123. Continuous Production Using a T-shaped Micro/milli-reactor for RUCY-catalyzed Asymmetric Hydrogenation of Acetophenone
Yamamoto, T.; Tonomura, O.; Nagaki, A.
J. Chem. Eng. Jpn. 2020, 53, 73–77.
DOI: 10.1252/jcej.19we083
122. Tf2O-mediated Reaction of Alkenyl Sulfoxides with Unprotected Anilines in Flow Microreactors
Baralle, A.; Inukai, T.; Yanagi, T.; Nogi, K.; Osuka, A.; Nagaki, A.; Yoshida, J.; Yorimitsu, H.
Chem. Lett. 2020, 49, 160–163.
DOI: 10.1246/cl.190831
121. A Novel Approach to Functionalization of Aryl Azides via Generation and Reactions of Organolithiums Bearing Masked Azides Using Flow Microreactors
Ichinari, D.; Ashikari, Y.; Mandai, K.; Aizawa, Y.; Yoshida, J.; Nagaki, A.
Angew. Chem. Int. Ed. 2020, 59, 1567–1571.
DOI: 10.1002/anie.201912419
Highlighted in Synfacts
120. 18O-Labeled chiral compounds enable the facile determination of enantioselectivity by mass spectroscopy
Mandai, K.; Tsuchihashi, Y.; Ashikari, Y.; Yoshida, J.; Nagaki, A.
Tetrahedron Lett. 2020, 61, 151367.
DOI: 10.1016/j.tetlet.2019.151367
119. Flow Technology for Genesis and Use of (Highly) Reactive Organometallic Reagents
Colella, M.; Nagaki, A.; Luisi, R.
Chem. Eur. J. 2020, 26, 19–32.
DOI: 10.1002/chem.201903353
118. フロー自動合成とAI(人工知能)を活用した研究・開発 ～現状の課題と将来展望～（第1部第1章）
永木愛一郎、清水悠、宅見正浩
117. 有機合成への応用技術と実用化事例（第2部第1章）
芦刈洋祐、永木愛一郎
マイクロリアクター/フロー合成による反応条件を最適化した導入と目的に応じた実生産への適用～事例をふまえた現状と課題 / 不具合を避けるための設備設計～
サイエンス＆テクノロジー社、2020年4月28日発刊、ISBN:978-4-86428-211-6
Link
2019
116. Oxo-Thiolation of Cationically Polymerizable Alkenes Using Flow Microreactors
Ashikari, Y.; Saito, K.; Nokami, T.; Yoshida, J.; Nagaki, A.
Chem. Eur. J. 2019, 25, 15239–15243.
DOI: 10.1002/chem.201903426
Selected as a cover picture
Link
115. Generation and Reaction of Functional Alkyllithiums Using Microreactors and Their Application to Heterotelechelic Polymer Synthesis
Nagaki, A.; Yamashita, H.; Hirose, K.; Tsuchihashi, Y.; Takumi, M.; Yoshida, J.
Chem. Eur. J. 2019, 25, 13719–13727.
DOI: 10.1002/chem.201902867
Selected as a cover picture
Cover Profile
Highlighted in Synfacts
114. Recent Topics of Functionalized Organolithiums using Flow Microreactor Chemistry
Nagaki, A.
Tetrahedron Lett. 2019, 60, 150923.
DOI: 10.1016/j.tetlet.2019.07.014
113. Practical Continuous Flow Controlled/Living Anionic Polymerization
Nakahara, Y.; Furusawa, M.; Endo, Y.; Shimazaki, T.; Takahashi, Y.; Jiang, Y.; Nagaki, A.
Chem. Eng. Technol. 2019, 42, 2154–2163.
DOI: 10.1002/ceat.201900160
112. Anionic Polymerizations using Flow Microreactors
Takahashi, Y.; Nagaki, A.
Molecules 2019, 24, 1532.
DOI: 10.3390/molecules24081532
111. Monolithiation of 5,5’-Dibromo-2,2’-bithiophene Using Flow Microreactors. Mechanistic Implications and Synthetic Applications
Nagaki, A.; Jiang, Y.; Yamashita, H.; Takabayashi, N.; Yoshida, J.
Chem. Eng. Technol. 2019, 42, 2113–2118.
DOI: 10.1002/ceat.201900057
110. Annulative Synthesis of Thiazoles and Oxazoles from Alkenyl Sulfoxides and Nitriles via Additive Pummerer Reaction
Hori, M.; Nogi, K.; Nagaki, A.; Yorimitsu, H.
Asian J. Org. Chem. 2019, 8, 1084–1087.
DOI: 10.1002/ajoc.201900169
109. Blockage Detection and Diagnosis of Externally Parallelized Monolithic Microreactors
Tonomura, O.; Taniguchi, S.; Nishi, K.; Nagaki, A.; Yoshida, J.; Hirose, K.; Ishizuka, N.; Hasebe, S.
Catalysts 2019, 9, 308.
DOI: 10.3390/catal9040308
108. Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-up by Series Connection of the Reactors
Nagaki, A.; Hirose, K.; Mitamura, K.; Matsukawa, K.; Ishizuka, N.; Yamamoto, T.; Takumi, M.; Takahashi, Y.; Yoshida, J.
Catalysts 2019, 9, 300.
DOI: 10.3390/catal9030300
107. Alkyllithiums Bearing Electrophilic Functional Groups: A Flash Chemistry Approach.
Nagaki, A.; Yamashita, H.; Hirose, K.; Tsuchihashi, Y.; Yoshida, J.
Angew. Chem. Int. Ed. 2019, 58, 4027–4030.
DOI: 10.1002/anie.201814088
106. Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums by Extremely Fast Micromixing.
Nagaki, A.; Sasatsuki, K.; Ishiuchi, S.; Miuchi, N.; Takumi, M.; Yoshida, J.
Chem. Eur. J. 2019, 25, 4946–4950.
DOI: 10.1002/chem.201900743
Highlighted in Synfacts
105. マイクロリアクターの研究開発状況とその展望
宅見正浩、永木愛一郎
「化学装置」工業通信, 2019, 61, 17–22.
104. Modeling and Design of Flow Microreactor-based Process for Synthesizing Ionic Liquids.
Nakahara, Y.; Metten, B.; Tonomura, O.; Nagaki, A.; Hasebe, S.; Yoshida, J.
Org. Process Res. Dev. 2019, 23, 641–647.
DOI: 10.1021/acs.oprd.8b00436
103. Molecular Weight Distribution of Polymers Produced by Anionic Polymerization Enables Mixability Evaluation.
Endo, Y.; Furusawa, M.; Shimazaki, T.; Takahashi, Y.; Nakahara, Y.; Nagaki, A.
Org. Process Res. Dev. 2019, 23, 635–640.
DOI: 10.1021/acs.oprd.8b00403
102. フローマイクロリアクターを用いた有機合成反応の選択性制御（第8章1節）
高橋裕輔、永木愛一郎
101. フローマイクロリアクターを用いた高分子合成反応とその連続運転（第8章4節）
永木愛一郎、中原祐一、遠藤裕太、高橋 裕輔
化学プロセスのスケールアップ、連続化 ―データ取得／装置・プロセス設計／生産性向上／トラブル対策―
技術情報協会、2019年3月31日発刊
ISBN: 978-4-86104-739-8. Link
2018
100. 高速マイクロ混合による反応選択性の高次制御
永木愛一郎、宅見正浩
月間ファインケミカル2018年12月号「フローマイクロ合成の最新動向I」
シーエムシー出版、2018年12月15日発刊
ISBN: 0913-6150. LINK
99. Transmission of Point Chirality to Axial Chirality for Strong Circular Dichroism in Triarylmethylium-o,o-dimers
Ishigaki, Y.; Iwai, T.; Hayashi, Y.; Nagaki, A.; Katoono, R.; Fujiwara, K.; Yoshida, J.; Suzuki, T.
Synlett 2018, 29, 2147–2154.
DOI: 10.1055/s-0037-1610190
98. Efficient Preparation of A Cyclic α-Alkylidene β-Oxo Imides Using a Microflow System
Komuro, K.; Nagaki, A.; Shimoda, H.; Uwamori, M.; Yoshida, J.; Nakada, M.
Synlett 2018, 29, 1989–1994.
DOI: 10.1055/s-0037-1610228
97. Flash Generation and Borylation of 1-(Trifluoromethyl)Vinyllithium toward Synthesis of α-(Trifluoromethyl)Styrenes
Fujita, T.; Konno, N.; Watabe, Y.; Ichitsuka, T.; Nagaki, A.; Yoshida, J.; Ichikawa, J.
J. Fluorine Chem. 2018, 207, 72–76.
DOI: 10.1016/j.jfluchem.2018.01.004
96. Selective Mono Addition of Aryllithiums to Dialdehydes by Micromixing
Nagaki, A.; Yamashita, H.; Takahashi, Y.; Ishiuchi, S.; Imai, K.; Yoshida, J.
Chem. Lett. 2018, 47, 71–73.
DOI: 10.1246/cl.170899
2017
95. “Impossible” Chemistries Based on Flow and Micro
Yoshida, J.; Kim, H.; Nagaki, A.
J. Flow Chem. 2017, 7, 60–64.
DOI: 10.1556/1846.2017.00017
94. Micromixing Enables Chemoselective Reactions of Difunctional Electrophiles with Functional Aryllithiums
Nagaki, A.; Ishiuchi, S.; Imai, K.; Sasatsuki, K.; Nakahara, Y.; Yoshida, J.
React. Chem. Eng. 2017, 2, 862–870.
DOI: 10.1039/C7RE00142H
93. Generation of Hazardous Methyl Azide and Its Application to Synthesis of a Key-Intermediate of Picarbutrazox, a New Potent Pesticide in Flow
Ichinari, D.; Nagaki, A.; Yoshida, J.
Bio. Med. Chem. 2017, 25, 6224–6228.
DOI: 10.1016/j.bmc.2017.07.005
92. フローマイクロリアクターの化学業界の動向（第III編第2章）
金熙珍、永木愛一郎、吉田潤一
フローマイクロ合成の実用化への展望（監修：吉田潤一）
シーエムシー出版、2017年1月11日発刊
ISBN: 978-4-7813-1232-3. Link
2016
91. Switching Between Intermolecular and Intramolecular Reactions Using Flow Microreactors. Lithiation of 2-Bromo-2′-Silylbiphenyls
Nagaki, A.; Kim, S.; Miuchi, N.; Yamashita, H.; Hirose, K.; Yoshida, J.
Org. Chem. Front. 2016, 3, 1250–1253.
DOI: 10.1039/C6QO00257A
90. Feasibility Study on Continuous Flow Controlled/Living Anionic Polymerization Processes.
Nagaki, A.; Nakahara, Y.; Furusawa, M.; Sawaki, T.; Yamamoto, T.; Toukairin, H.; Tadokoro, S.; Shimazaki, T.; Ito, T.; Otake, M.; Arai, H.; Higashida, N.; Takahashi, Y.; Moriwaki, Y.; Tsuchihashi, Y.; Hirose, K.; Yoshida, J.
Org. Process Res. Dev. 2016, 20, 1377–1382.
DOI: 10.1021/acs.oprd.6b00158
89. Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three-Component Synthesis of Functionalized a-Ketoamides.
Nagaki, A.; Takahashi, Y.; Yoshida, J.
Angew. Chem., Int. Ed. 2016, 55, 5327–5331
DOI: 10.1002/anie.201601386
Selected as a cover picture
88. Integration of Borylation of Aryllithiums and Suzuki-Miyaura Coupling Using Monolithic Pd Catalyst
Nagaki, A.; Hirose, K.; Moriwaki, Y.; Mitamura, K.; Matsukawa, K.; Ishizuka, N.; Yoshida, J.
Catal. Sci. Technol. 2016, 6, 4690–4694.
DOI: 10.1039/C5CY02098K
87. Design of a Numbering-up System of Monolithic Microreactors and Its Application to Synthesis of a Key Intermediate of Valsartan
Nagaki, A.; Hirose, K.; Tonomura, O.; Taga, T.; Taniguchi, S.; Hasebe, S.; Ishizuka, N.; Yoshida, J.
Org. Process Res. Dev. 2016, 20, 687–691.
DOI: 10.1021/acs.oprd.5b00414
86. Flash Cationic Polymerization Followed by Bis-end-functionalization. A New Approach to Linear-Dendritic Hybrid Polymers.
Tani, Y.; Takumi, M.; Moronaga, S.; Nagaki, A.; Yoshida, J.
Eur. Poly. J. 2016, 80, 227–233.
DOI: 10.1016/j.eurpolymj.2016.02.021
85. Flow microreactor synthesis of 2,2-disubstituted oxetanes via 2-phenyloxetan-2-yl lithium
Degennaro, L.; Nagaki, A.; Moriwaki, Y.; Romanazzi, G.; DelľAnna, M. M.; Yoshida, J.; Luisi, R.
Open Chem. 2016, 14, 377–382.
DOI: 10.1515/chem-2016-0041
84. Organometallic Flow Chemistry
Nagaki, A.; Yoshida, J.
Top. Organomet. Chem. 2016, 57, 137–175.
DOI: 10.1007/3418_2015_154
83. Flow Microreactor Polymerization
Nagaki, A.
ケミカルエンジニヤリング 2016, 61(9), 683–692.
82. マイクロ流路を利用した空間的反応集積化
吉田潤一、金熙珍、永木愛一郎
化学と工業 2016, 69, 117–119. Link (pdf)
2015
81. Polymerization of Vinyl Ethers Initiated by Dendritic Cations Using Flow Microreactors
Nagaki, A.; Takumi, M.; Tani, Y.; Yoshida, J.
Tetrahedron 2015, 71, 5973–5978.
DOI: 10.1016/j.tet.2015.05.096
80. Organolithiums Bearing Aldehyde Carbonyl Groups. A Flash Chemistry Approach
Nagaki, A.; Tsuchihashi, Y.; Haraki, S.; Yoshida, J.
Org. Biomol. Chem. 2015, 13, 7140–7145.
DOI: 10.1039/C5OB00958H
79. Reactions of Difunctional Electrophiles with Functionalized Aryllithium Compounds: Remarkable Chemoselectivity by Flash Chemistry.
Nagaki, A.; Imai, K.; Ishiuchi, S.; Yoshida, J.
Angew. Chem., Int. Ed. 2015, 54, 1914–1918.
DOI: 10.1002/anie.201410717
78. Flash Chemistry Using Trichlorovinyllithium. Switching the Reaction Pathways by High-Resolution Reaction Time Control.
Nagaki, A.; Takahashi, Y.; Henseler, A.; Matsuo, C.; Yoshida, J.
Chem. Lett. 2015, 44, 214–216.
DOI: 10.1246/cl.140980
77. Reaction Integration Using Electrogenerated Cationic Intermediates.
Yoshida, J.; Shimizu, A.; Ashikari, Y.; Morofuji, T.; Hayashi, R.; Nokami, T.; Nagaki, A.
Bull. Chem. Soc. Jpn. 2015, 88, 763-775.
DOI: 10.1246/bcsj.20150100
76. Synthetic Chemistry in Flow Microreactors.
Nagaki, A.
J. Syn. Org. Chem., Jpn. 2015, 73, 423-434.
DOI: 10.5059/yukigoseikyokaishi.73.423
75. 高速マイクロ混合とフロー合成
吉田潤一、永木愛一郎
ながれ 2015, 34, 3–9.
74. フラッシュケミストリー──フラスコではできない合成化学を目指して
吉田潤一、永木愛一郎、金熙珍、市成大輔
月刊化学 2015年4月号（2015/03/18発刊）Link
2014
73. Three-Component Coupling Based on Flash Chemistry. Carbolithiation of Benzyne with Functionalized Aryllithiums Followed by Reactions with Electrophiles
Nagaki, A.; Ichinari, D.; Yoshida, J.
J. Am. Chem. Soc. 2014, 136, 12245–12248.
DOI: 10.1021/ja5071762
72. Flow Microreactor Synthesis of Fluorine-Containing Block Copolymers
Nagaki, A.; Akahori, K.; Takahashi, Y.; Yoshida, J.
J. Flow Chem. 2014, 4, 168–172.
DOI: 10.1556/JFC-D-14-00017
71. Flash Generation of α-(Trifluoromethyl)vinyllithium and Application to Continuous Flow Three-Component Synthesis of α-Trifluoromethylamides
Nagaki, A.; Tokuoka, S.; Yoshida, J.
Chem. Commun. 2014, 50, 15079–15081.
DOI: 10.1039/C4CC06709F
70. Extremely Fast Gas/Liquid Reactions in Flow Microreactors: Carboxylation of Short-Lived Organolithiums
Nagaki, A.; Takahashi, Y.; Yoshida, J.
Chem. Eur. J. 2014, 20, 7931–7934.
DOI: 10.1002/chem.201402520
69. Expandability of Ultralong CC Bonds: Largely Different C1C2 Bond Lengths Determined by Low-temperature X-ray Structural Analyses on Pseudopolymorphs of 1,1-Bis(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)pyracene
Suzuki, T.; Uchimura, Y.; Nagasawa, F.; Takeda, T.; Kawai, H.; Katoono, R.; Fujiwara, K.; Murakoshi, K.; Fukushima, T.; Nagaki, A.;Yoshida, J.
Chem. Lett. 2014, 43, 86–88.
DOI: 10.1246/cl.130872
68. 有機金属反応（第11章）
永木愛一郎
67. 重合反応（第18章）
永木愛一郎
フロー・マイクロ合成 基礎から実際の合成・製造まで（吉田潤一 編）
化学同人、2014年7月24日発刊、ISBN: 978-4759814170
66. Microreactor Technology in Lithium Chemistry (Chapter 17)
Nagaki, A.; Yoshida, J.
Lithium Compounds in Organic Synthesis – From Fundamentals to Applications (Edited by Renzo Luisi and Vito Capriati)
Wiley-VCH, published in March 19 2014, ISBN: 978-3527333431
2013
65. Reactions of Organolithiums with Dialkyl Oxalates. A Flow Microreactor Approach to Synthesis of Functionalized a-Keto Esters
Nagaki, A.; Ichinari, D.; Yoshida, J.
Chem. Commun. 2013, 49, 3242–3244.
DOI: 10.1039/c3cc40392k
64. Synthesis of Functionalized Aryl Fluorides Using Organolithium Reagents in Flow Microreactors
Nagaki, A.; Uesugi, Y.; Kim, H.; Yoshida, J.
Chem. Asian J. 2013, 8, 705–708.
DOI: 10.1002/asia.201201191
63. Generation and Reactions of Pyridyllithiums via Br/Li Exchange Reactions Using Continuous Flow Microreactor Systems
Nagaki, A.; Yamada, D.; Yamada, S.; Doi, M.; Ichinari, D.; Tomida, Y.; Takabayashi, N.; Yoshida, J.
Aust. J. Chem. 2013, 66, 199–207.
DOI: 10.1071/CH12440
62. Synthesis of 1,2,3,4-Tetrahydroisoquinolines by Microreactor-Mediated Thermal Isomerization of Laterally Lithiated Arylaziridines
Giovine, A.; Musio, B.; Degennaro, L.; Falcicchio, A.; Nagaki, A.; Yoshida, J.; Luisi, R.
Chem. Eur. J. 2013, 19, 1872–1876.
DOI: 10.1002/chem.201203533
61. Controlled Polymerization in Flow Microreactor Systems.
Nagaki, A.; Yoshida, J.
Controlled Polymerization and Polymeric Structures, Vol. 259, Springer-Verlag, 2013, pp1–50.
DOI: 10.1007/12_2012_179
60. マイクロリアクターによる有機リチウム化学の新展開
永木 愛一郎
有機合成化学協会誌 2013, 71, 1002–1019.
DOI: 10.5059/yukigoseikyokaishi.71.1002
59. マイクロリアクターによる有機リチウム化学の新展開
永木愛一郎
化学と工業 2013, 66 (11), 924–925. Link
58. Continuous Flow Synthesis
Yoshida, J.; Nagaki, A.; Yamada, D.
Drug Discovery Today, 2013, 10, e53–e59.
DOI: 10.1016/j.ddtec.2012.10.013
57. Flow Microreactor Synthesis in Organofluorine Chemistry
Amii, H.; Nagaki, A.; Yoshida, J.
Beilstein J. Org. Chem. 2013, 9, 2793–2802.
DOI: 10.3762/bjoc.9.314
56. Flash Chemistry: Flow Chemistry That Cannot Be Done in Batch
Yoshida, J.; Takahashi, Y.; Nagaki, A.
Chem. Commun. 2013, 49, 9896–9904.
DOI: 10.1039/C3CC44709J
55. マイクロリアクターによる有機リチウム化学への新展開
永木愛一郎
化学とマイクロ・ナノシステム学会誌 2013, 12 (2), 30.
54. Flash Chemistry: New Synthetic Chemistry Using Flow Microreactors
Yoshida, J.; Takahashi, Y.; Nagaki, A.
Kagaku Kogaku 2013, 77, 785–787.
53. Electrochemical Reactions in Microreactors (Chapter 9)
Yoshida, J.; Nagaki, A.
Microreactors in Preparative Chemistry (edited by Wladimir Reschetilowski)
Wiley-VCH, published July 19 2013, ISBN: 9783527332823. Link
2012
52. Lithiation of 1,2-Dichloroethene in Flow Microreactors. Versatile Synthesis of Alkenes and Alkynes by Precise Residence-Time Control.
Nagaki, A.; Matsuo, C.; Kim, S.; Saito, K.; Miyazaki, A.; Yoshida, J.
Angew. Chem. Int. Ed. 2012, 51, 3245–3248.
DOI: 10.1002/anie.201108932
51. Flow Synthesis of Arylboronic Esters Bearing Electrophilic Functional Groups and Space Integration with Suzuki–Miyaura Coupling without Intentionally Added Base.
Nagaki, A.; Moriwaki, Y.; Yoshida, J.
Chem. Commun. 2012, 48, 11211–11213.
DOI: 10.1039/C2CC36197C
50. Flash Generation of a Highly Reactive Pd Catalyst for Suzuki–Miyaura Coupling by Using a Flow Microreactor.
Nagaki, A.; Takabayashi, N.; Moriwaki, Y.; Yoshida, J.
Chem. Eur. J. 2012, 18, 11871–11875.
DOI: 10.1002/chem.201201579
49. Practical Synthesis of Photochromic Diarylethenes in Integrated Flow Microreactor Systems.
Asai, T.; Takata, A.; Nagaki, A.; Yoshida, J.
ChemSusChem 2012, 5, 339–350.
DOI: 10.1002/cssc.201100376
48. Flow Microreactor Synthesis of Tricyclic Sulfonamides via N-tosylaziridinyllithiums.
Takizawa, E.; Nagaki, A.; Yoshida, J.
Tetrahedron Lett. 2012, 53, 1397–1400.
DOI: 10.1016/j.tetlet.2012.01.019
47. Cross-coupling of Aryllithiums with Aryl and Vinyl Halides in Flow Microreactors.
Nagaki, A.; Moriwaki, Y.; Haraki, S.; Kenmoku, A.; Hayashi, A.; Yoshida, J.
Chem. Asian J. 2012, 7, 1061–1068.
DOI: 10.1002/asia.201101019
46. Generation and Reactions of Vinyllithiums Using Flow Microreactor Systems.
Nagaki, A.; Takahashi, Y.; Yamada, S.; Matsuo, C.; Haraki, S.; Moriwaki, Y.; Kim, S.; Yoshida, J.
J. Flow Chem. 2012, 2, 70–72.
DOI: 10.1556/JFC-D-12-00004
45. Non-additive Substituent Effects on Expanding Prestrained C–C Bond in Crystal: X-ray Analyses on Unsymmetrically Substituted Tetraarylpyracenes Prepared by a Flow Microreactor Method
Suzuki, T.; Uchimura, Y.; Ishigaki, Y.; Takeda, T.; Katoono, R.; Kawai, H.; Fujiwara, K.; Nagaki, A.; Yoshida, J.
Chem. Lett. 2012, 41, 541–543.
DOI: 10.1246/cl.2012.541
44. Living Anionic Polymerization of tert-Butyl Acrylate in a Flow Microreactor System and Its Applications to the Synthesis of Block Copolymers.
Nagaki, A.; Takahashi, Y.; Akahori, K.; Yoshida, J.
Macromol. React. Eng. 2012, 6, 467–472.
DOI: 10.1002/mren.201200051
43. マイクロリアクターを使った環境調和型有機合成、高分子合成技術
Nagaki, A.; Yoshida, J.
マイクロリアクター技術の最前線（監修：前一廣）
シーエムシー出版、2012年5月17日発刊、ISBN: 978-4-7813-0587-5
42. フローマイクロリアクター合成化学：時間を空間で制御する新しい化学
永木愛一郎、吉田潤一
化学と教育 2012, 60 (5), 190–193.
2011
41. Perfluoroalkylation in Flow Microreactor: Generation of Perfluoroalkyllithiums in the Presence and Absence of Electrophiles.
Nagaki, A.; Tokuoka, S.; Yamada, S.; Tomida, Y.; Oshiro, K.; Amii, H.; Yoshida, J.
Org. Biomol. Chem. 2011, 9, 7559–7563.
DOI: 10.1039/C1OB06350B
40. Homocoupling of Aryl Halides in Flow: Space Integration of Lithiation and FeCl3 Promoted Homocoupling.
Nagaki, A.; Uesugi, Y.; Tomida, Y.; Yoshida, J.
Beilstein J. Org. Chem. 2011, 7, 1064–1069.
DOI: 10.3762/bjoc.7.122
39. Hysteretic Tricolor Electrochromic Systems Based on the Dynamic Redox Properties of Unsymmetrically Substituted Dihydrophenanthrenes and Biphenyl-2,2′-Diyl Dications: Efficient Precursor Synthesis by a Flow Microreactor Method.
Ishigaki, Y.; Suzuki, T.; Nishida, J.; Nagaki, A.; Takabayashi, N.; Kawai, H.; Fujiwara, K.; Yoshida, J.
Materials 2011, 4, 1906–1926.
DOI: 10.3390/ma4111906
38. Flash Synthesis of TAC-101 and Its Analogues from 1,3,5-Tribromobenzene Using Integrated Flow Microreactor Systems.
Nagaki, A.; Imai, K.; Kim, H.; Yoshida, J.
RSC Adv. 2011, 1, 758–760.
DOI: 10.1039/C1RA00377A
37. Flow Microreactor Synthesis of Disubstituted Pyridines from Dibromopyridines via Br/Li Exchange without Using Cryogenic Conditions.
Nagaki, A.; Yamada, S.; Doi, M.; Tomida, Y.; Takabayashi, N.; Yoshida, J.
Green Chem. 2011, 13, 1110–1113.
DOI: 10.1039/C0GC00852D
36. A Flow Microreactor Approach to Protecting-group-free Synthesis Using Organolithium Compounds.
Kim, H.; Nagaki, A.; Yoshida, J.
Nat. Commun. 2011, 2, 264.
DOI: 10.1038/ncomms1264
35. Switching Reaction Pathways of Benzo[b]thiophen-3-yllithium and Benzo[b]furan-3-yllithium Based on High-Resolution Residence-Time and Temperature Control in a Flow Microreactor.
Asai, A.; Takata, A.; Ushiogi, Y.; Iinuma, Y.; Nagaki, A.; Yoshida, J.
Chem. Lett. 2011, 40, 393–395.
DOI: 10.1246/cl.2011.393
34. Asymmetric Carbolithiation of Conjugated Enynes: A Flow Microreactor Enables the Use of Configurationally Unstable Intermediates before They Epimerize.
Tomida, Y.; Nagaki, A.; Yoshida, J.
J. Am. Chem. Soc. 2011, 133, 3744–3747.
DOI: 10.1021/ja110898s
33. Anionic Polymerization of Alkyl Methacrylates using Flow Microreactor Systems.
Nagaki, A.; Miyazaki, A.; Tomida, Y.; Yoshida, J.
Chem. Eng. J. 2011, 167, 548–555.
DOI: 10.1016/j.cej.2010.07.073
32. マイクロリアクターを用いたイオン重合とその精密構造制御ポリマー合成への応用
永木愛一郎
高分子論文集 2011, 68, 521–531.
DOI: 10.1295/koron.68.521
31. マイクロリアクターによる有機リチウム化学の新展開
永木愛一郎、富田裕、吉田潤一
ケミカルエンジニアリング 2011, 56, 54–63.
30. Space Integration of Reactions: An Approach to Increase Capability of Organic Synthesis
Yoshida, J.; Saito, K.; Nokami, T.; Nagaki, A.
Synlett, 2011, 9, 1189–1194.
DOI: 10.1055/s-0030-1259946
29. Green and Sustainable Chemical Synthesis Using Flow Microreactors
Yoshida, J.; Kim, H.; Nagaki, A.
ChemSusChem. 2011, 4, 331–340.
DOI: 10.1002/cssc.201000271
2010
28. Generation and Reactions of Oxiranyllithiums by Use of a Flow Microreactor System.
Nagaki, A.; Takizawa, E.; Yoshida, J.
Chem. Eur. J. 2010, 16, 14149–14158.
DOI: 10.1002/chem.201000815
27. Synthesis of Polystyrenes-Poly(alkyl methacrylates) Block Copolymers via Anionic Polymerization Using an Integrated Flow Microreactor System.
Nagaki, A.; Miyazaki, A.; Yoshida, J.
Macromolecules 2010, 43, 8424–8429.
DOI: 10.1021/ma101663x
26. A Flow Microreactor System Enables Organolithium Reactions without Protecting Alkoxycarbonyl Groups.
Nagaki, A.; Kim, H.; Moriwaki, Y.; Matsuo, C.; Yoshida, J.
Chem. Eur. J. 2010, 16, 11167–11177.
DOI: 10.1002/chem.201000876
25. Cross-Coupling in a Flow Microreactor: Space Integration of Lithiation and Murahashi Coupling.
Nagaki, A.; Kenmoku, A.; Moriwaki, Y.; Hayashi, A.; Yoshida, J.
Angew. Chem. Int. Ed. 2010, 49, 7543–7547.
DOI: 10.1002/anie.201002763
24. Generation and Reaction of Cyano-substituted Aryllithium Compounds Using Microreactors.
Nagaki, A.; Kim, H.; Usutani, H.; Matsuo, C.; Yoshida, J.
Org. Biomol. Chem. 2010, 8, 1212–1217.
DOI: 10.1039/B919325C
23. Building Addressable Libraries as Platforms for Biological Assays by an Electrochemical Method
Yoshida, J.; Nagaki, A.
Angew. Chem., Int. Ed. 2010, 49, 3720–3722.
DOI: 10.1002/anie.201000046
22. マイクロリアクターを用いた重合反応の制御
永木愛一郎、吉田潤一
高分子 2010, 59, 569–573.
2009
21. Nitro-Substituted Aryl Lithium Compounds in Microreactor Synthesis: Switch between Kinetic and Thermodynamic Control.
Nagaki, A.; Kim, H.; Yoshida, J.
Angew. Chem. Int. Ed. 2009, 48, 8063–8065.
DOI: 10.1002/anie.200904316
20. Generations and Reactions of N–t-butylsulfonylaziridinyllithiums Using Microreactors.
Nagaki, A.; Takizawa, E.; Yoshida, J.
Chem. Lett. 2009, 38, 1060–1061.
DOI: 10.1246/cl.2009.1060
19. Microflow System Controlled Anionic Polymerization of Alkyl Methacrylates.
Nagaki, A.; Tomida, Y.; Miyazaki. A.; Yoshida, J.
Macromolecules 2009, 42, 4384–4387.
DOI: 10.1021/ma900551a
18. Carbolithiation of Conjugated Enynes with Aryllithiums in Microflow System and Applications to Synthesis of Allenylsilanes.
Tomida, Y.; Nagaki, A.; Yoshida, J.
Org. Lett. 2009, 11, 3614–3617.
DOI: 10.1021/ol901352t
17. Synthesis of Unsymmetrically Substituted Biaryls via Sequential Lithiation of Dibromobiaryls Using Integrated Microflow Systems.
Nagaki, A.; Takabayashi, N.; Tomida, Y.; Yoshida, J.
Beilstein J. Org. Chem. 2009, 5, 16.
DOI: 10.3762/bjoc.5.16
16. Generation and Reactions of alpha-Silyloxiranyllithium in a Microreactor.
Nagaki, A.; Takizawa, E.; Yoshida, J.
Chem. Lett. 2009, 38, 486–487.
DOI: 10.1246/cl.2009.486
15. Oxiranyl Anion Methodology Using Microflow Systems.
Nagaki, A.; Takizawa, E.; Yoshida, J.
J. Am. Chem. Soc. 2009, 131, 1654–1655 and 3787.
DOI: 10.1021/ja809325a
2008
14. Aryllithium Compounds Bearing Alkoxycarbonyl Groups: Generation and Reactions Using a Microflow System.
Nagaki, A.; Kim, H., Yoshida, J.
Angew. Chem. Int. Ed. 2008, 47, 7833–7836.
DOI: 10.1002/anie.200803205
13. Selective Monolithiation of Dibromobiaryls Using Microflow Systems.
Nagaki, A.; Takabayashi, T.; Tomida, Y.; Yoshida, J.
Org. Lett. 2008, 10, 3937–3940.
DOI: 10.1021/ol8015572
12. Microflow System Controlled Anionic Polymerization of Styrenes.
Nagaki, A.; Tomida, Y.; Yoshida, J.
Macromolecules 2008, 17, 6322–6330.
DOI: 10.1021/ma800769n
11. Microflow System Controlled Carbocationic Polymerization of Vinyl Ethers.
Nagaki, A.; Iwasaki, T.; Kawamura, K.; Yamada, D.; Suga, S.; Ando, T.; Sawamoto, M.; Yoshida, J.
Chem. Asian J. 2008, 3, 1558–1567.
DOI: 10.1002/asia.200800081
2007
10. Integrated Micro Flow Synthesis Based on Sequential Br-Li Exchange Reactions of p-, m-, and o-Dibromobenzenes.
Nagaki, A.; Tomida, Y.; Usutani, H.; Kim, H.; Takabayashi, N.; Nokami, T.; Okamoto, H.; Yoshida, J.
Chem. Asian J. 2007, 2, 1513–1523.
DOI: 10.1002/asia.200700231
9. Generation and Reactions of o-Bromophenyllithium without Benzyne Formation Using a Microreactor.
Usutani, H.; Tomida, T.; Nagaki, A.; Okamoto, H.; Nokami, T.; Yoshida, J.
J. Am. Chem. Soc. 2007, 129, 3046–3047.
DOI: 10.1021/ja068330s
8. Microsystem Controlled Cationic Polymerization of Vinyl Ethers Initiated by CF3SO3H.
Iwasaki, T.; Nagaki, A.; Yoshida, J.
Chem. Commun. 2007, 1263–1265.
DOI: 10.1039/b615159k
before 2006
7. Control of Extremely Fast Competitive Consecutive Reactions Using Micromixing. Selective Friedel-Crafts Aminoalkylation.
Nagaki, A.; Togai, M.; Suga, S.; Aoki, N.; Mae, K.; Yoshida, J.
J. Am. Chem. Soc. 2005, 127, 11666–11675.
DOI: 10.1021/ja0527424
6. Cycloaddition of “N-Acyliminium Ion Pools” with Carbon-Carbon Multiple Bonds.
Suga, S.; Tsutsui, Y.; Nagaki, A.; Yoshida, J.
Bull. Chem. Soc. Jpn. 2005, 78, 1206–1271.
DOI: 10.1246/bcsj.78.1206
5. マイクロリアクターを用いた選択的有機反応
吉田潤一、菅誠治、永木愛一郎
有機合成化学協会誌 2005, 63, 511–522.
DOI: 10.5059/yukigoseikyokaishi.63.511
4. “Cation Pool” Initiated Controlled/Living Polymerization Using Microsystems.
Nagaki, A.; Kawamura, K.; Suga, S.; Ando, T.; Sawamoto, M.; Yoshida, J.
J. Am. Chem. Soc. 2004, 126, 14702–14703.
DOI: 10.1021/ja044879k
3. Three-Component Coupling Based on the “Cation Pool” Method.
Suga, S.; Nishida, T.; Yamada, D.; Nagaki, A.; Yoshida, J.
J. Am. Chem. Soc. 2004, 126, 14338–14339.
DOI: 10.1021/ja0455704
2. “N-Acyliminium Ion Pool” as Hetero Diene in [4+2] Cycloaddition Reaction.
Suga, S.; Nagaki, A.; Tsutsui, Y.; Yoshida, J.
Org. Lett. 2003, 5, 945–947.
DOI: 10.1021/ol0341243
1. Highly Selective Friedel-Crafts Monoalkylation Using Micromixing.
Suga, S.; Nagaki, A.; Yoshida, J.
Chem. Commun. 2003, 354–355.
DOI: 10.1039/b211433j